Jul 21, 2019 | Updated: 08:54 AM EDT

First Ever Fully Synthetic Anti-Malaria Drug Acts As Single-Dose Prevention

May 25, 2017 09:02 AM EDT

Malaria Carriers
(Photo : Mario Tama/Getty Images) Fully synthetic malaria preventive drug innovated by a group of multinational team of researchers; know more here

The treatment techniques and elimination formats of malaria have long been focused on artemisinin-based combination strategies (ACTs). The format combines artemisinin-based drugs based on semi-synthetic drug partners. But the search for fully-synthetic drugs to heal this superlative disease has been the subject for a wide range of research. Perhaps, a new finding can be considered as a ray of hope in this context, as a group of multinational researchers has discovered a one-dose element for curing malaria.

According to Phys Org, a team of researchers belonging from LSTM in association with another group of scientists from the University of Liverpool have raised this new fully-synthetic component. The molecule, namely E209, meets the key requirement for drug-based treatment of malaria. The element demonstrates key feature for potential prevention against those of malaria initiating parasites. According to the researchers, the molecule also provides trustworthy eliminative measures against those elements which even resist, the traditional artemisinin-based treatment.

Science Daily pointed that the growing resistance against ACTs based remedies has been a crucial issue in terms of malaria prevention. But with the E209 molecule, which has been regarded as a single dose treatment for prevention against malaria initiating parasites, can also effectively handle and prevent such ACTs' rejections.

The study has been an eye-opener in terms of malaria prevention, as Professor Paul O'Neill of the University of Liverpool, stated: "E209 is a second-generation peroxide based drug, designed at Liverpool, with significant improvements over the gold standard antimalarial treatment artesunate. E209 contains a unique core with two endoperoxide units; through medicinal chemistry optimization, the stability, potency, and pharmacokinetics of this class have now been optimized."

The finding was recently published in the well-known journal 'Nature Communications.' E209 has now been recognized by scientists globally. The researchers' also believed that this innovation would pave new ways for the creation of new potential techniques for the prevention of malaria parasites. 

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