Jan 15, 2019 | Updated: 01:26 PM EST

Estee Lauder Companies To Launch Six Abstracts Focusing On Anti-Aging Skin, Hair Research

Apr 27, 2017 01:54 AM EDT


Estée Lauder Companies, a known American manufacturer, and marketer of makeup, skincare, fragrance and hair care products, will present six abstracts poster that would focus on new findings in anti-aging skin and hair research at the 76th Annual Meeting of the Society for Investigative Dermatology. It would be held on April 26 to April 29 in Portland, Oregon.

Kurt Schilling, the senior vice president of basic science research and advanced technology, research and development of Estee Lauder Companies, said the research and development department of the company is focused on bringing new avenues in industry-leading skin and hair research. He added that leaders in the cosmetic industry with scientific heritage, they have been at the forefront of many areas of research like skin and hair structure and architecture, repair and protection, inflammation and reactivity.

"We (Estee Lauder Companies) have applied this emerging knowledge, along with our expertise in formulations, to deliver unique beauty solutions that balance the effects of nature and nurture for our consumers," Schilling has said.

The research would be summarized into six. The first one is the harmful effects of pollen exposure on skin physiology. Eureka Alert has reported that this study of Estee Lauder Companies R&D evaluates the physiological effects of pollen exposure on skin, especially on the changes in inflammatory response, skin barrier function, and collagen levels. It also measures how treatment with antioxidants mitigates these detrimental effects.

Protection against photo-aging by targeting the transient receptor potential channel, TRPV1. This in-vitro study of Estee Lauder Companies R&D will be focusing on in-vitro will demonstrate TRPV1 as a significant contributor to photoaging. It would make an important target for photoprotection while highlighting the beneficial effects of an antioxidant called 4-t-butylcyclohohexanol in protecting against UV and IR-induced damage.

Energy enhancing compounds protect against IR-induced barrier disruption in reconstructed skin models. Another hypothesized mech of IR-induced damage is through alterations in energy metabolism. In-vitro treatment with energy enhancing materials, pre-IR radiation exposure could reduce the severity of barrier damage and treatment post-IR radiation that could restore the barrier completely by suggesting the compounds optimize mitochondrial energy production.

Melatonin receptors decrease with age in normal human dermal fibroblasts. The data collected by Estee Lauder Companies R&D demonstrate a reduction in melatonin receptors because of the function of age. Elle UK has reported that the data suggests the importance of modulating these receptors in order to re-establish a natural circadian rhythm in skin cells.

Biomechanics & periorbital aging is also included. Stress, induced by a profound level of repetitive tissue movements that could impact skin cells and scaffolding, explain why eye skin ages faster than its surrounding facial skin. These results found by Estee Lauder Companies R&D show how repetitive skin micromovements could impact skin cells over time and their scaffolding explains why periorbital skin aging is accelerated.

Last is the prevention of H2O2-induced cellular senescence in human hair follicle dermal papilla cells. By developing a high screening assay in assessing the ability of actives to stimulate the proliferation of hair follicle dermal papilla cells and protect against H2O2-induced senescence.

There are three types of activities were observed by Estee Lauder Companies R&D. First, actives that stimulated cellular proliferation without an observable protection against H2O2-induced senescence. Second, actives that stimulated cellular proliferation and protected against H2O2-induced senescence. Third,  Actives that protected against H2O2-induced senescence with no cellular proliferative activity.

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